The defender had to be replaced by Matthew Connolly after an hour of Saturday's 2-1 win over Nottingham Forest as he was suffering with an illness.
Boss Iain Dowie will also have to make at least one change to his bench, with back-up goalkeeper Lee Camp set to join Nottingham Forest on loan having lost his first-team spot to Radek Cerny this season.
Teenage striker Angelo Balanta will hope to keep his place after scoring the opening goal at the weekend, while Akos Buzsaky proved his fitness following his summer ankle surgery with a stunning second.
Rowan Vine is the Hoops' only long-term absentee as he continues to battle back from a broken leg.
Swansea midfielder Thomas Butler is facing a race against time to feature.
The winger missed the victory against Wolves two weeks ago with a groin injury and was only a late substitute for the 2-2 draw at Ipswich at the weekend.
Butler has now aggravated the knock and faces a late fitness test as Roberto Martinez's men aim for a victory that could see them leapfrog Rangers and move into the play-off positions.
Spanish midfielder Andrea Orlandi is another doubt as he is struggling to overcome a thigh problem that ruled him out of the Portman Road clash.
Wales Under-21 midfielder Shaun MacDonald suffered a slight ankle injury in the European Championship qualifying play-off defeat to England last week but is expected to return.
Sporting Life