The winger this week joined the west Londoners from Aston Villa and should go straight into Paulo Sousa's squad.
Lee Cook, who on Thursday made his loan move from Fulham permanent, has been struggling with a virus all week so Routledge could be named in the the starting XI.
Heidar Helguson and Gary Borrowdale will also hope to play their first games as permanent Rangers players.
Centre-half Fitz Hall is back in contention after a knock kept him out of last weekend's goalless FA Cup draw against Burnley.
Lee Camp, Zesh Rehman and Adam Bolder are back at the club following their recent loan spells but are unlikely to figure while Akos Buzsaky (knee) and Rowan Vine (leg) are still out.
Coventry boss Chris Coleman will be forced to make at least two changes to his starting line-up when the Sky Blues travel to Loftus Road to face QPR.
Striker Robbie Simpson is out for up to three weeks after sustaining a thigh injury in the FA Cup victory over Kidderminster while City's misfortune with defensive injuries continued this week with Marcus Hall's freak accident in training.
The full-back suffered a severed septum - the piece of skin that separates the nostrils - after a coming-together with team-mate Leon Best and is not expected to travel.
Hall's absence once again leaves Coleman short at the back with Elliott Ward struggling with a knee problem and Scott Dann (shoulder) and Isaac Osbourne (ankle) still out. Dan Fox could offer some relief after a recent bout of illness.
Goalkeeper Dimi Konstantopoulos, who was recalled from his loan spell at Swansea last week and was on the bench against Kidderminster, has since returned to the south Wales club until the end of the month.
Sporting Life